| Title | Subacute cutaneous lupus erythematosus induced by terbinafine: case report and review of literature. | | Author(s) | Lorentz K, Booken N, Goerdt S, Goebeler M | | Institution | Department of Dermatology, Venerology, and Allergology, University Clinic of Mannheim, Medical School of Mannheim at the University of Heidelberg, Germany. | | Source | J Dtsch Dermatol Ges 2008 Jun 17. | | Abstract | Systemic lupus erythematosus and subacute cutaneous lupus erythematosus (SCLE) occasionally evolve as adverse reactions to a large variety of chemically different drugs. We here report on a 76-year-old woman who developed SCLE within 10 days after initiation of oral terbinafine. Analysis of the 27 cases of terbinafine-induced SCLE in the literature revealed that this disorder has been reported 6 times more often in females than in males. Skin lesions evolved on average around 7 weeks after starting the drug. In 79% of the cases ANA could be detected while antibodies against Ro/SS-A and La/SS-B were found in 86% and 39%, respectively. Remarkably, anti-histone antibodies were present in only 29%. In all cases terbinafine-induced SCLE resolved after discontinuation of the triggering agent. Systemic treatment with anti-malarials and/or corticosteroids does not appear to be mandatory. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18564209 |
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