Expression of oncostatin M in chronic obstructive sialadenitis of the submandibular gland. The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] Journal article | | Title | Expression of oncostatin M in chronic obstructive sialadenitis of the submandibular gland. | | Author(s) | Lee HM, Cho JG, Kang HJ, Chae SW, Hwang SJ, Jung KY, Woo JS | | Institution | Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. | | Source | Ann Otol Rhinol Laryngol 2008 May; 117(5):347-52. | | MeSH | Adult
Biological Markers
Blotting, Western
Chronic Disease
Constriction, Pathologic
Female
Follow-Up Studies
Gene Expression
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Male
Middle Aged
Oncostatin M
Prognosis
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Sialadenitis
Submandibular Gland
| | Abstract | OBJECTIVES: We investigated the expression of oncostatin M messenger RNA (mRNA) and protein in normal submandibular glands and those with chronic obstructive sialadenitis and localized the expression of oncostatin M protein.
METHODS: Submandibular glands from 10 patients with chronic obstructive sialadenitis as a study group and 10 normal submandibular glands as a control group were examined. Oncostatin M mRNA extracted from submandibular gland was used for reverse transcription-polymerase chain reaction and analyzed semiquantitatively. The difference in expression level of oncostatin M protein between the 2 groups was analyzed through Western blot analysis, and oncostatin M protein was localized immunohistochemically.
RESULTS: The expression levels of oncostatin M mRNA and protein were significantly increased in the study group. The protein was predominantly localized in ductal epithelia and infiltrating inflammatory cells and was more strongly expressed in the study group also.
CONCLUSIONS: Oncostatin M is expressed in both chronic obstructive sialadenitis and normal submandibular gland, and is up-regulated in chronic obstructive sialadenitis. These results suggest that oncostatin M is involved in the pathologic process of chronic obstructive sialadenitis. However, the physiologic role in normal glands, as well as a possible role in the development of chronic obstructive sialadenitis, remains to be elucidated. | | Language | eng | | Pub Type(s) | Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18564531 |
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