Hernández-Sierra JF, Ruiz F, Cruz Pena DC, Martínez-Gutiérrez F, Martínez AE, de Jesús Pozos Guillén A, Tapia-Pérez H, Martínez Castañón G
The antimicrobial sensitivity of Streptococcus mutans to nanoparticles of silver, zinc oxide, and gold. [JOURNAL ARTICLE]
Nanomedicine 2008 Jun 17.
Dental caries is a worldwide public health problem for which Streptococcus mutans has been identified as the possible infectious etiology. In recent years nanotechnology has permitted the development of new properties of materials. The objective of this study was to compare the bactericidal and bacteriostatic effects of nanoparticles of silver, zinc oxide, and gold on S. mutans. We used the liquid dilution method to find the minimum inhibitory concentrations (MICs) and with subcultures obtained the minimum bactericidal concentrations (MBCs). For silver the results showed an average MIC of 4.86 +/- 2.71 mug/mL and MBC of 6.25 mug/mL; for zinc the MIC was 500 +/- 306.18 mug/mL and MBC of 500 mug/mL; the gold nanoparticles demonstrated an effect only at an initial concentration of 197 mug/mL. We established a higher antimicrobial effect against S. mutans of silver nanoparticles at lower concentrations than gold or zinc, which would allow achieving important clinical effects with a reduced toxicity.
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