Hunder NN, Wallen H, Cao J, Hendricks DW, Reilly JZ, Rodmyre R, Jungbluth A, Gnjatic S, Thompson JA, Yee C
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. [Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't]
N Engl J Med 2008 Jun 19; 358(25):2698-703.
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
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