| Title | Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. | | Author(s) | Hunder NN, Wallen H, Cao J, Hendricks DW, Reilly JZ, Rodmyre R, Jungbluth A, Gnjatic S, Thompson JA, Yee C | | Institution | Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. | | Source | N Engl J Med 2008 Jun 19; 358(25):2698-703. | | MeSH | Antibodies, Neoplasm
Antigens, Neoplasm
CD4-Positive T-Lymphocytes
Humans
Immunoglobulin G
Immunotherapy
Male
Melanoma
Membrane Proteins
Middle Aged
Remission Induction
| | Abstract | We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 18565862 |
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