| Title | Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement. | | Author(s) | Chiou AC, Andrade SS, Almeida SC, Zanella RC, Andrade AL, Brandileone MC | | Institution | 1Bacteriology Department, Adolfo Lutz Institute, São Paulo, Brazil. | | Source | J Med Microbiol 2008 Jul; 57(Pt 7):839-44. | | Abstract | In Brazil, serotype 1 Streptococcus pneumoniae is one of the most prevalent causes of severe infection. This study investigated the genetic relatedness of 134 serotype 1 isolates obtained from invasive diseases during the period 1977-2005. Molecular typing by PFGE revealed two major lineages using visual inspection and computer analysis. Type A comprised 94 isolates (70.2 %) with four subtypes, whereas type B comprised 40 isolates (29.8 %) with eight subtypes. Subtype A3, the most frequent genotype, accounting for 65 % of the total isolates, was identified as a representative of clone Sweden(1)-40 (ST304). Type B was predominant in the period 1977-1988. In contrast, an increase in the type A lineage was detected from 1990 in Brazil, significantly associated with isolates recovered from pneumonia cases and from young patients. This study clearly established a temporal switch between two lineages of S. pneumoniae serotype 1 in Brazil, with a wide dispersion of clone Sweden(1)-40 in recent years. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18566141 |
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