| Title | [Oxidative stress in porphyria and carriers] | | Author(s) | Aminaka M, Kondo M, Takata A, Yamauchi H, Ikeda M, Yoshida K | | Institution | Department of Preventive Medicine, St. Marianna University School of Medicine, Kawasaki, Japan. m2ami@marianna-u.ac.jp | | Source | Nippon Eiseigaku Zasshi 2008 May; 63(3):628-35. | | Abstract | We sought to establish a causal relationship between oxidative stress and porphyria in patients and carriers. We reported changes in urinary porphyrin concentrations related to 8-hydroxy-2'-deoxyguanosine.
METHODS: We measured urinary 8-hydroxy-2'-deoxyguanosine concentration in porphyria patients and carriers with multifactorial inheritance as a possible marker of attack. The porphyria types included 10 patients with porphyria cutanea tarda, 5 with variegate porphyria, 8 with hereditary coproporphyria, 7 with congenital erythropoietic porphyria, 5 with erythropoietic protoporphyria, 5 with acute intermittent porphyria, 7 erythropoietic protoporphyria carriers, and 7 acute intermittent porphyria carriers.
RESULTS: Urinary porphyrin concentrations in these patients were significantly higher than those in healthy subjects (p<0.001). Urinary 8-hydroxy-2'-deoxyguanosine concentrations were significantly high in dermatopathy porphyria types namely porphyria cutanea tarda (p<0.001), variegate porphyria (p<0.05), hereditary coproporphyria (p<0.05), congenital erythropoietic phyria (p<0.05), and erythropoietic protoporphyria (p<0.001).
CONCLUSION: These results reveal that urinary 8-hydroxy-2'-deoxyguanosine concentration in cutis porphyria types is a good predictor of attack and abatement. | | Language | jpn | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 18567368 |
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