Preparation, characterization, and evaluation of liposomal ferulic Acid in vitro and in vivo. Drug development and industrial pharmacy [Drug Dev Ind Pharm] Journal article | | Title | Preparation, characterization, and evaluation of liposomal ferulic Acid in vitro and in vivo. | | Author(s) | Qin J, Chen D, Lu W, Xu H, Yan C, Hu H, Chen B, Qiao M, Zhao X | | Institution | Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China. | | Source | Drug Dev Ind Pharm 2008 Jun; 34(6):602-8. | | Abstract | In the present study, various gradients were evaluated for efficient loading of weak acid into liposomes. Several salt gradients showed efficient loading of ferulic acid (FA) into liposomes and the optimized conditions were established in calcium acetate gradient method to obtain 80.2 +/- 5.2% entrapment efficiency (EE). Unilamellar vesicles were observed in micrographs and liposomal FA showed good stability. 80% of FA was released from liposomes within 5 h in vitro. There is a novel finding in this study: that drugs could be entrapped with a high solubility in the intraliposomal buffer in contrast to the low solubility in the extraliposomal buffer. The results of body distribution in rats indicated that liposomes could improve the body distribution of FA. For FA liposome, the concentration of FA in brain was two-fold higher than that of free FA. Liposomal FA was a promising approach to improve the body distribution of FA. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18568910 |
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