| Title | A histologic review of 27 patients with lichen planopilaris. | | Author(s) | Tandon YK, Somani N, Cevasco NC, Bergfeld WF | | Institution | Faculty of Medicine, North Eastern Ohio Universities College of Medicine, Rootstown, Ohio, USA. | | Source | J Am Acad Dermatol 2008 Jul; 59(1):91-8. | | MeSH | Adult
Aged
Alopecia
Biopsy
Cicatrix
Female
Humans
Lichen Planus
Male
Middle Aged
Retrospective Studies
Scalp
Scalp Dermatoses
| | Abstract | BACKGROUND: Lichen planopilaris (LPP) is a potential trichologic emergency that can result in permanent scarring alopecia. Histopathology is a key component of the diagnostic work-up.
OBJECTIVE: To identify the key histologic features that characterize LPP in order to facilitate diagnosis, ultimately leading to improved patient outcomes.
METHODS: Scalp biopsy specimens from 27 confirmed cases of LPP were reviewed in a blinded fashion to determine diagnostically helpful histologic features.
RESULTS: Absence of arrector pili muscles and sebaceous glands, a perivascular and perifollicular lymphocytic infiltrate in the reticular dermis and mucinous perifollicular fibroplasia within the upper dermis with absence of interfollicular mucin, and superficial perifollicular wedge-shaped scarring were characterizing features.
LIMITATIONS: Sample size was limited, given that biopsy specimens were taken from lesions at varying stages of evolution and findings vary with disease stage.
CONCLUSIONS: This study confirms many previously reported histologic features and highlights new characterizing features of mucinous perifollicular fibroplasia. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18571598 |
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