| Title | Myocardial regenerative therapy: immunologic basis for the potential "universal donor cells". | | Author(s) | Atoui R, Shum-Tim D, Chiu RC | | Institution | Division of Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada. | | Source | Ann Thorac Surg 2008 Jul; 86(1):327-34. | | MeSH | Animals
Cells, Cultured
Disease Models, Animal
Forecasting
Graft Rejection
Graft Survival
Heart Function Tests
Myocardial Infarction
Myocardial Ischemia
Stem Cell Transplantation
Transplantation Conditioning
Transplantation Immunology
Transplantation, Autologous
Treatment Outcome
Ventricular Remodeling
| | Abstract | Stem cell transplantation is a promising approach for improving cardiac function after severe myocardial damage for which use of autologous donor cells have been preferred to avoid immune rejection. Recently however, rodent, porcine, and even human bone marrow stromal cells have been reported to be uniquely immune tolerant, both in the in vitro mixed lymphocyte co-culture studies and in the in vivo allo-transplant and xeno-transplant models. In this review, we explore the current understanding of the underlying immunologic mechanisms, which can facilitate the use of such cells as "universal donor cells" with fascinating therapeutic implications. | | Language | eng | | Pub Type(s) | In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Review
| | PubMed ID | 18573459 |
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