| Title | Genetic factors in drug metabolism. | | Author(s) | Belle DJ, Singh H | | Institution | Oregon State University College of Pharmacy, Portland Campus at Oregon Health & Science University, Portland, Oregon 97239, USA. | | Source | Am Fam Physician 2008 Jun 1; 77(11):1553-60. | | MeSH | Anti-Asthmatic Agents
Asthma
Cytochrome P-450 Enzyme System
Drug Interactions
Humans
Pharmaceutical Preparations
Pharmacogenetics
Pharmacokinetics
Pharmacology
Phenotype
Polymorphism, Genetic
Variation (Genetics)
| | Abstract | Patients vary widely in their response to drugs. Having an understanding of the pharmacokinetic and pharmacodynamic properties of various medications is importantwhen assessing ethnic differences in drug response. Genetic factors can account for 20 to 95 percent of patient variability. Genetic polymorphisms for many drug-metabolizing enzymes and drug targets (e.g., receptors) have been identified. Although currently limited to a few pathways, pharmacogenetic testing may enable physicians to understand why patients react differently to various drugs and to make better decisions about therapy. Ultimately, this understanding may shift the medical paradigm to highly individualized therapeutic regimens. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 18581835 |
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