| Title | Simultaneous determination of adenosine and inosine using single-wall carbon nanotubes modified pyrolytic graphite electrode. | | Author(s) | Goyal RN, Gupta VK, Chatterjee S | | Institution | Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. | | Source | Talanta 2008 Jul 30; 76(3):662-8. | | Abstract | Voltammetric determination of adenosine and inosine has been carried out at single-wall carbon nanotubes (SWNTs) modified pyrolytic graphite electrode (PGE) at pH 7.2 using Osteryoung square wave voltammetry (OSWV). The modified electrode exhibits remarkable electrocatalytic properties towards adenosine and inosine oxidation with a peak potential of approximately 1229mV and 1348mV, respectively. Linear calibration curves are obtained over the concentration range 0.5muM to 1.0mM in adenosine and 10muM to 1.0mM in inosine with sensitivity of 1.0muAmuM(-1) and 1.9muAmuM(-1) for adenosine and inosine respectively. The limit of detection for adenosine and inosine was found to be 0.51x10(-7)M and 2.04x10(-7)M, respectively. The proposed method was also used to estimate these compounds in human blood plasma and urine samples and the method was validated using HPLC. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18585336 |
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