| Title | Echinococcus granulosus: Induction of T-independent antibody response against protoscolex glycoconjugates in early experimental infection. | | Author(s) | Baz A, Carol H, Fernández V, Mourglia-Ettlin G, Nieto A, Orn A, Dematteis S | | Institution | Cátedra de Inmunología, Dpto. Biociencias, Facultad de Química, Universidad de la República, Casilla de Correos 1157, Montevideo, Uruguay. | | Source | Exp Parasitol 2008 May 14. | | Abstract | In this work CD4-knockout mice were used as a model to analyse the role of CD4(+) T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens. After infection, CD4-knockout mice and C57Bl/6 mice showed similar titres of specific antibodies indicating that T-independent antibody production was quantitatively important in early infection. We have also identified an antigenic fraction from protoscoleces (E4(+)) which induces CD4 T cell independent antibody response in early stages of infection. In conclusion, the results presented here directly support the existence of T-independent immunogens in E. granulosus protoscoleces and suggest that T-independent antibody response may be quantitatively important in early infection. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18585710 |
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