Hogan AM, Tricotet T, Meek A, Khokhar SS, O'Shea DF
Applications of Enantioselective Carbolithiation of Ortho-Substituted beta-Methylstyrenes. [JOURNAL ARTICLE]
J Org Chem 2008 Jun 28.
The enantioselective carbolithiation of ortho-substituted ( E)-beta-methylstyrenes provides access to chiral lithiated intermediates with broad synthetic potential. Specifically, beta-methylstyrenes with o-aminomethyl, ether, and oxazoline groups have been employed in the synthesis of chiral aromatics and heteroaromatics such as isoquinolines, isoquinolinones, benzofurans, and isobenzofuranones.
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