| Title | Applications of Enantioselective Carbolithiation of Ortho-Substituted beta-Methylstyrenes. | | Author(s) | Hogan AM, Tricotet T, Meek A, Khokhar SS, O'Shea DF | | Source | J Org Chem 2008 Jun 28. | | Abstract | The enantioselective carbolithiation of ortho-substituted ( E)-beta-methylstyrenes provides access to chiral lithiated intermediates with broad synthetic potential. Specifically, beta-methylstyrenes with o-aminomethyl, ether, and oxazoline groups have been employed in the synthesis of chiral aromatics and heteroaromatics such as isoquinolines, isoquinolinones, benzofurans, and isobenzofuranones. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18588347 |
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