| Title | Diabetes risk begins in utero. | | Author(s) | Woo M, Patti ME | | Institution | Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA. | | Source | Cell Metab 2008 Jul; 8(1):5-7. | | Abstract | Both intrauterine and postnatal environments contribute to diabetes risk. A recent paper highlights epigenetic mechanisms underlying beta cell dysfunction associated with intrauterine growth retardation, including repressive histone modification and DNA methylation during postnatal life. Thus, intrauterine stress can initiate a disturbing epigenetic cascade of progressive transcriptional repression linked to beta cell failure. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18590686 |
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