Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study. Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] Journal article | | Title | Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study. | | Author(s) | Singh-Manoux A, Gimeno D, Kivimaki M, Brunner E, Marmot MG | | Institution | INSERM U687-IFR69, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France. Archana.Singh-Manoux@inserm.fr | | Source | Arterioscler Thromb Vasc Biol 2008 Aug; 28(8):1556-62. | | Abstract | OBJECTIVE: The purpose of this study was to examine the relationship between fasting serum lipids and short-term verbal memory in middle-aged adults.
METHODS AND RESULTS: Total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides, and memory were measured twice, at mean ages 55 and 61, in 3673 male and female participants of the Whitehall II study. Short-term verbal memory was assessed using a 20-word list. Logistic regression was used to model associations between ATP-III categories of lipids and memory deficit (recall of < or =4 words) and decline (decrease of > or =2 words). Analyses were adjusted for education, occupational position, coronary heart disease, stroke, hypertension, use of medication, diabetes, smoking, and alcohol consumption. Compared to high HDL-C (> or =60 mg/dL), low HDL-C (<40 mg/dL) was associated with greater odds of memory deficit at the first (OR=1.27; 95% confidence interval [CI]=0.91 to 1.77) and second wave of this study (OR=1.53; 95% CI=1.04 to 2.25) in fully adjusted analysis. Decrease in HDL-C over the 5-year follow-up period was associated with decline in memory in the adjusted analysis (OR=1.61; 95% CI=1.19 to 2.16); no interaction with APOE e4 status was present.
CONCLUSIONS: HDL-C levels are potentially modifiable, and our results suggest that low HDL-C is associated with poor memory and decline in memory in middle-aged adults. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
| | PubMed ID | 18591462 |
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