| Title | Treatment of Coronary Spastic Angina With a Statin in Addition to a Calcium Channel Blocker: A Pilot Study. | | Author(s) | Tani S, Nagao K, Anazawa T, Kawamata H, Furuya S, Takahashi H, Iida K, Fuji T, Matsumoto M, Kumabe T, Sato Y, Hirayama A | | Institution | From the *Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, Japan;and the daggerDivision of Cardiovascular Medicine, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. | | Source | J Cardiovasc Pharmacol 2008 Jun 26. | | Abstract | Combined therapy with a statin and a calcium channel blocker, which can improve lipid metabolism and reduce oxidative stress, may attenuate coronary vasoconstriction in patients with coronary spastic angina (CSA). After 6 months of therapy with benidipine and pravastatin, an acetylcholine provocation test was performed a second time in 25 patients with CSA. The patients were divided into 2 groups according to whether the result of this second test was positive (n = 13) or negative (n = 12). The test was designated as positive when the intracoronary injection of acetylcholine induced angiographically demonstrable total or subtotal occlusion (positive-test group). In the negative-test group, significant decrease in the plasma levels of low-density lipoprotein (LDL) cholesterol (-20.7 +/- 11.1%, P < 0.01 versus baseline) were observed along with a dramatic increase in the serum level of high-density lipoprotein (HDL) cholesterol (26.8 +/- 13.2%, P < 0.01 versus baseline). Furthermore, a significant decrease of the malondialdehyde-modified low-density lipoprotein (MDA-LDL) level, a marker of oxidative stress, was also observed (-22.6 +/- 14.1%, P < 0.01 versus baseline) in this group. In the positive-test group, however, no significant changes were found in any of the aforementioned parameters. The results showed that improvement of lipid metabolism, especially an increase of HDL cholesterol level and a reduction of MDA-LDL, may inhibit vascular contractility. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18594477 |
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