Cimprich KA, Cortez D
ATR: an essential regulator of genome integrity. [Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't]
Nat Rev Mol Cell Biol 2008 Aug; 9(8):616-27.
Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.
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