| Title | Partial Salvage Cryoablation of the Prostate for Recurrent Prostate Cancer After Radiotherapy Failure. | | Author(s) | Eisenberg ML, Shinohara K | | Institution | Department of Urology, University of California-San Francisco, San Francisco, California. | | Source | Urology 2008 Jul 1. | | Abstract | OBJECTIVES: To determine the efficacy of partial cryoablation of the prostate in the salvage setting.
METHODS: All patients who were treated between April 2004 and September 2007 for recurrent prostate adenocarcinoma after failure of primary radiotherapy by means of partial cryoablation were identified.
RESULTS: Nineteen patients met inclusion criteria; 15 had >6 months' follow-up. Mean age was 71 years. Men received salvage therapy a mean of 6 years after primary radiotherapy. Median follow-up was 18 months (range, 6-33 months). The biochemical recurrence-free survival rate (according to the American Society for Therapeutic Radiology and Oncology definition) was 89%, 67%, and 50% at 1, 2, and 3 years, respectively. One of 10 patients harbored residual carcinoma on routine follow-up biopsy at 1 year, whereas 50% harbored residual benign prostate tissue. Complications included incontinence (1), urethral stricture (1), and urethral ulcer (1).
CONCLUSIONS: In properly selected patients with a unilateral focus of disease recurrence after radiotherapy, acceptable oncologic results can be achieved with partial cryoablation of the prostate, with low morbidity. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18597824 |
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