| Title | Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. | | Author(s) | Tang B, Cheng G, Gu JC, Xu CH | | Institution | School of Pharmacy, P.O. Box 32, Shenyang Pharmaceutical University, 103 WenHua Road, Shenyang City 110016, Liaoning Province, PR China. | | Source | Drug Discov Today 2008 Jul; 13(13-14):606-612. | | Abstract | Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Conventional SEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, solid SEDDS (S-SEDDS), prepared by solidification of liquid/semisolid self-emulsifying (SE) ingredients into powders, have gained popularity. This article gives an overview of the recent advances in the study of S-SEDDS, especially the related solidification techniques and the development of solid SE dosage forms. Finally, the existing problems and the possible future research directions in this field are pointed out. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18598917 |
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