Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science (New York, N.Y.) [Science] Journal article

Title	Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.
Author(s)	Audero E, Coppi E, Mlinar B, Rossetti T, Caprioli A, Banchaabouchi MA, Corradetti R, Gross C
Institution	Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00015 Monterotondo, Italy.
Source	Science 2008 Jul 4; 321(5885):130-3.
MeSH	Animals Autonomic Nervous System Autoreceptors Body Temperature Doxycycline Electrocardiography Feedback, Biochemical Heart Rate Homeostasis Humans Infant Mice Mice, Transgenic Motor Activity Neural Inhibition Neurons Piperazines Pyridines Raphe Nuclei Receptor, Serotonin, 5-HT1A Serotonin Serotonin Antagonists Sudden Infant Death Sympathetic Nervous System Synaptic Transmission Tryptophan
Abstract	Sudden infant death syndrome is the leading cause of death in the postneonatal period in developed countries. Postmortem studies show alterations in serotonin neurons in the brainstem of such infants. However, the mechanism by which altered serotonin homeostasis might cause sudden death is unknown. We investigated the consequences of altering the autoinhibitory capacity of serotonin neurons with the reversible overexpression of serotonin 1A autoreceptors in transgenic mice. Overexpressing mice exhibited sporadic bradycardia and hypothermia that occurred during a limited developmental period and frequently progressed to death. Moreover, overexpressing mice failed to activate autonomic target organs in response to environmental challenges. These findings show that excessive serotonin autoinhibition is a risk factor for catastrophic autonomic dysregulation and provide a mechanism for a role of altered serotonin homeostasis in sudden infant death syndrome.
Language	eng
Pub Type(s)	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
PubMed ID	18599790

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