An Unusual Patient with Hypothyroidism, Tophaceous Gout, and Marked Joint Destruction. Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] Journal article | | Title | An Unusual Patient with Hypothyroidism, Tophaceous Gout, and Marked Joint Destruction. | | Author(s) | Montoya F, Torres RJ, Fraile JM, Puig JG | | Institution | Divisions of Internal Medicine, La Paz University Hospital, Madrid. | | Source | Nucleosides Nucleotides Nucleic Acids 2008 Jun; 27(6):604-607. | | Abstract | This report describes a 75-year-old Caucasian man with extensive urate deposits and severe gouty arthropathy that confined him to a wheelchair. Since age 50, he suffered multiple acute gout flares and progressive deformities in his hands, feet, knees, and elbows (tophi). Serum creatinine was 1.4 mg/dL and serum urate 9.4 mg/dL. Conditions known to increase uric acid production (psoriasis, chronic bronchitis) and to decrease uric acid excretion (hypothyroidism, metabolic syndrome, and nephroangiosclerosis) may operate in a single patient, illustrating the dramatic clinical course of untreated gout. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18600513 |
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