Effect of Acarbose on the Increased Plasma Concentration of Uric Acid Induced by Sucrose Ingestion. Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] Journal article | | Title | Effect of Acarbose on the Increased Plasma Concentration of Uric Acid Induced by Sucrose Ingestion. | | Author(s) | Moriwaki Y, Inokuchi T, Ka T, Yamamoto A, Tsutsumi Z, Takahashi S, Yamamoto T | | Institution | Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. | | Source | Nucleosides Nucleotides Nucleic Acids 2008 Jun; 27(6):631-633. | | Abstract | Sucrose is converted fructose and glucose, which may increase plasma uric acid concentration (pUA) through increased purine degradation and/or decreased uric acid (UA) excretion. To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose. Sucrose raised pUA by 10% (p < 0.01). However, excretion and fractional clearance of UA were unchanged. Sucrose and acarbose coadministration also increased pUA, but less than did sucrose alone (sucrose: 4.9 to 5.4 mg/dl; sucrose + acarbose, 4.7 to 4.9 mg/dl, p < 0.05) without changes in urinary excretion and fractional clearance of UA. Acarbose appears to attenuate the rise in pUA by sucrose ingestion by inhibiting sucrose absorption. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18600518 |
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