Ecto-5'-Nucleotidase (Cd73)-Mediated Extracellular Adenosine Production Plays a Critical Role in Hepatic Fibrosis. Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] Journal article

In previous studies, we have demonstrated that adenosine and its receptors play a role in hepatic fibrosis. Here, we review evidence that toxin-induced increases in hepatic adenosine concentrations are generated from adenine nucleotides by the action of ecto-5'nucleotidase and thus that adenosine-mediated, toxin-induced hepatic fibrosis depends on extracellular conversion of adenine nucleotides to adenosine.

Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids]