Ecto-5'-Nucleotidase (Cd73)-Mediated Extracellular Adenosine Production Plays a Critical Role in Hepatic Fibrosis. Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] Journal article | | Title | Ecto-5'-Nucleotidase (Cd73)-Mediated Extracellular Adenosine Production Plays a Critical Role in Hepatic Fibrosis. | | Author(s) | Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, Cronstein BN | | Institution | Department of Medicine, Divisions of Clinical Pharmacology and Rheumatology, New York University School of Medicine, New York, New York, USA. | | Source | Nucleosides Nucleotides Nucleic Acids 2008 Jun; 27(6):821-824. | | Abstract | In previous studies, we have demonstrated that adenosine and its receptors play a role in hepatic fibrosis. Here, we review evidence that toxin-induced increases in hepatic adenosine concentrations are generated from adenine nucleotides by the action of ecto-5'nucleotidase and thus that adenosine-mediated, toxin-induced hepatic fibrosis depends on extracellular conversion of adenine nucleotides to adenosine. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18600546 |
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