| Title | Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. | | Author(s) | Peixoto F, Camargos A, Duarte G, Linhares I, Bahamondes L, Petracco A | | Institution | Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil. | | Source | Int J Gynaecol Obstet 2008 Jul 4. | | Abstract | OBJECTIVE: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.
METHODS: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.
RESULTS: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated.
CONCLUSION: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18603245 |
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