Differential Diagnosis between Osteomyelitis and Bone Tumors. Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] Journal article | | Title | Differential Diagnosis between Osteomyelitis and Bone Tumors. | | Author(s) | Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Ochi M | | Institution | Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. | | Source | Acta Radiol 2008 Jul 10.:1-6. | | Abstract | Background: Hematogenous osteomyelitis is often difficult to distinguish from a bone tumor because clinical findings are noncontributory and radiological features can mimic a bone tumor. Recently, the penumbra sign, a higher signal intensity feature of the thin layer of granulation tissue which lines the abscess cavity on T1-weighted magnetic resonance (MR) images, has been reported to be helpful for discriminating subacute osteomyelitis.
Purpose: To determine helpful findings for distinguishing osteomyelitis from bone tumors. Material and
Methods: The laboratory and imaging findings of a consecutive series of 244 patients referred to our institution with a suspected bone tumor were reviewed. There were 15 cases of osteomyelitis, 160 bone tumors, and 69 tumor-like lesions.
Results: In osteomyelitis, the C-reactive protein (CRP) level increased in nine patients and the penumbra sign was seen in 11 patients. In bone tumors and tumor-like lesions, a high CRP level was observed in 21 patients and the penumbra sign was seen in two patients. The sensitivity of the penumbra sign for osteomyelitis was 73.3%, with a specificity of 99.1%.
Conclusion: The penumbra sign and a high CRP level support the diagnosis of osteomyelitis and may help to exclude the presence of a tumor. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18615335 |
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