| Title | Folate and Vitamin B(6) Intake and Risk of Colon Cancer in Relation to p53 Expression. | | Author(s) | Schernhammer ES, Ogino S, Fuchs CS | | Institution | Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Ludwig Boltzmann Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria; Applied Cancer Research - Institute for Translational Research Vienna, Vienna, Austria. | | Source | Gastroenterology 2008 Jun 12. | | Abstract | BACKGROUND & AIMS: Considerable evidence suggests that a low-folate diet increases the risk of colorectal cancer, although the results of a recent randomized trial indicate that folate supplementation may not reduce the risk of adenoma recurrence. In laboratory models, folate deficiency appears to induce p53 mutation.
METHODS: We immunohistochemically assayed p53 expression in paraffin-fixed colon cancer specimens in a large prospective cohort of women with 22 years of follow-up to examine the relationship of folate intake and intake of other one-carbon nutrients to risks by tumor p53 expression.
RESULTS: A total of 399 incident colon cancers accessible for p53 expression were available. The effect of folate differed significantly according to p53 expression (P(heterogeneity) = .01). Compared with women reporting folate intake <200 mug/day, the multivariate relative risks (RRs) for p53-overexpressing (mutated) cancers were 0.54 (95% confidence interval [CI], 0.36-0.81) for women who consumed 200-299 mug/day, 0.42 (95% CI, 0.24-0.76) for women who consumed 300-399 mug/day, and 0.54 (95% CI, 0.35-0.83) for women who consumed >/=400 mug/day. In contrast, total folate intake had no influence on wild-type tumors (RR, 1.05; 95% CI, 0.73-1.51; comparing >/=400 with <200 mug/day). Similarly, high vitamin B(6) intake conferred a protective effect on p53-overexpressing cancers (top versus bottom quintile: RR, 0.57; 95% CI, 0.35-0.94; P(heterogeneity) = .01) but had no effect on p53 wild-type tumors.
CONCLUSIONS: We found that low folate and vitamin B(6) intake was associated with an increased risk of p53-overexpressing colon cancers but not wild-type tumors. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18619459 |
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