Choi KM, Gang J, Yun J
Anti-Toxoplasma gondii RH strain activity of herbal extracts used in traditional medicine. [JOURNAL ARTICLE]
Int J Antimicrob Agents 2008 Jul 9.
Methanolic extracts of 15 traditional medicines used to treat Toxoplasma gondii were tested in vitro for their anti-T. gondii activity and cytotoxicity. The median effective concentration (EC(50)) values for the herbal extracts ranged from 0.11mg/mL to 2.28mg/mL. Significant anti-T. gondii RH strain activity was observed with Zingiber officinale extracts (EC(50)=0.18mg/mL), which displayed a highly selective toxicity (selectivity=10.1). Sophora flavescens Aiton extracts also showed high anti-T. gondii activity (EC(50)=0.20mg/mL) and a high selective toxicity (4.6). This indicates that Z. officinale and S. flavescens Aiton extracts may be sources of new anti-T. gondii compounds.
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