Antimicrobial peptides, skin infections, and atopic dermatitis. Seminars in cutaneous medicine and surgery [Semin Cutan Med Surg] Journal article | | Title | Antimicrobial peptides, skin infections, and atopic dermatitis. | | Author(s) | Hata TR, Gallo RL | | Institution | Division of Dermatology, University of California San Diego, San Diego, CA. | | Source | Semin Cutan Med Surg 2008 Jun; 27(2):144-50. | | Abstract | The innate immune system evolved more than 2 billion years ago to first recognize pathogens then eradicate them. Several distinct defects in this ancient but rapidly responsive element of human immune defense account for the increased incidence of skin infections in atopics. These defects include abnormalities in the physical barrier of the epidermis, alterations in microbial pattern recognition receptors such as toll receptors and nucleotide binding oligomerization domains, and a diminished capacity to increase the expression of antimicrobial peptides during inflammation. Several antimicrobial peptides are affected including; cathelicidin, HBD-2, and HBD-3, which are lower in lesional skin of atopics compared with other inflammatory skin diseases, and dermcidin, which is decreased in sweat. Other defects in the immune defense barrier of atopics include a relative deficiency in plasmacytoid dendritic cells. In the future, understanding the cause of these defects may allow therapeutic intervention to reduce the incidence of infection in atopic individuals and potentially decrease the severity of this disorder. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18620136 |
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