| Title | Hypertrophic Osteoarthropathy Effectively Treated with Zoledronic Acid. | | Author(s) | King MM, Nelson DA | | Institution | Department of Hematology/Oncology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX. | | Source | Clin Lung Cancer 2008 May 1; 9(3):179-182. | | Abstract | Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by digital clubbing, arthralgias, and tissue swelling and is frequently described in association with bronchogenic carcinoma. The associated pain can be disabling, and symptoms are often resistant to conventional analgesic medications. We present a patient with HOA of the lower extremities and wrists that developed after bronchogenic carcinoma. The pain and swelling completely resolved after a single administration of 4 mg of zoledronic acid. The proposed pathogenesis of HOA and the mechanisms by which bisphosphonates might alleviate symptoms are reviewed. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18621629 |
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