Wąsicki J, Kozlenko DP, Pankov SE, Bilski P, Pajzderska A, Hancock BC, Medek A, Nawrocik W, Savenko BN
NMR search for polymorphic phase transformations in chlorpropamide form-A at high pressures. [JOURNAL ARTICLE]
J Pharm Sci 2008 Jul 11.
The high-pressure effects on chlorpropamide (C(10)H(13)ClN(2)O(3)S) form-A have been studied by (1)H NMR spectroscopy at high pressures up to 800 MPa in the temperature range 90-300 K. A study of the NMR second moment and spin-lattice relaxation time has been completed by a calculation of the steric hindrances for molecular reorientations and simulations of the second moment of the NMR line by the Monte-Carlo method, which enabled a precise description of molecular dynamics in the compound studied. Reorientations of the methyl group, oscillations and reorientations of the chlorophenyl ring and reorientations of the propyl group have been revealed and respective activation parameters extracted. No phase transformation of the compound form-A has been detected. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.
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