| Title | Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate. | | Author(s) | Laqueur GL, McDaniel EG, Matsumoto H | | Institution | Laboratory of Experimental Pathology National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014, USA. | | Source | J Natl Cancer Inst 1967 Aug; 39(2):355-71. | | MeSH | Animals
Carcinogens
Cycasin
Female
Germ-Free Life
Hydrolysis
Injections, Intraperitoneal
Male
Methylazoxymethanol Acetate
Mitosis
Neoplasms, Experimental
Protein Synthesis Inhibitors
Rats
| | Abstract | The glucoside cycasin, an effective hepatotoxin and carcinogen in conventional rats, fails to produce these effects when administered to germfree rats. The hepatotoxic and carcinogenic effects of cycasin can also be elicited after prior hydrolysis to the aglycone. The aglycone (MAM) and the synthetic aglycone acetate ester produce all the effects in germfree rats of which the intact glucoside is capable only when fed to conventional rats. The aglycone is therefore the proximate carcinogen. Its liberation from the glucoside in conventional rats is mediated in the intestinal tract by a beta-glucosidase of bacterial origin. Intraperitoneal administration of the synthetic aglycone acetate and the free aglycone appears to be the most effective route for tumor induction and, of these resulting tumors, the most frequent are in the intestinal tract. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
| | PubMed ID | 18623950 |
|
