| Title | Host Restriction Factors Blocking Retroviral Replication. | | Author(s) | Wolf D, Goff SP | | Institution | HHMI, Department of Biochemistry and Molecular Biophysics, and Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032. | | Source | Annu Rev Genet 2008 Jul 14. | | Abstract | Retroviruses are highly successful intracellular parasites, and as such they are found in nearly all branches of life. Some are relatively benign, but many are highly pathogenic and can cause either acute or chronic diseases. Therefore, there is tremendous selective pressure on the host to prevent retroviral replication, and for this reason cells have evolved a variety of restriction factors that act to inhibit or block the viruses. This review is a survey of the best-characterized restriction factors capable of inhibiting retroviral replication and aims to highlight the diversity of strategies used for this task. Expected final online publication date for the Annual Review of Genetics Volume 42 is November 3, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18624631 |
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