| Title | Renal Lesions Associated with IgM-Secreting Monoclonal Proliferations: Revisiting the Disease Spectrum. | | Author(s) | Audard V, Georges B, Vanhille P, Toly C, Deroure B, Fakhouri F, Cuvelier R, Belenfant X, Surin B, Aucouturier P, Mougenot B, Ronco P | | Institution | Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris (APHP), Institut Francilien de recherche en Néphrologie et Transplantation, INSERM U 841, University of Paris 12, Créteil, France; Nephrology Department, Centre hospitalier de Namur, Namur, Belgium; Nephrology Department, Hôpital de Valenciennes, Valenciennes, France; Hematology and Immunology Department, Hôpital Tenon, APHP, Université Pierre et Marie Curie (UPMC) University of Paris 06, Paris, France; ||Hôpital Saint Antoine, INSERM, UMR S 712, APHP, UPMC University of Paris 06, Paris, France; paragraph signNephrology and Renal Transplantation Department, Hôpital Kremlin Bicêtre, APHP, Le Kremlin Bicêtre, France; **Nephrology Department, Hôpital Necker, APHP, University of Paris 05, Paris, France; Nephrology Department, Centre hospitalier de Mouscron, Mouscron, Belgium; Nephrology Department, Hôpital de Montreuil, Montreuil, France; INSERM UMR S 702; UPMC University of Paris 06, Paris, France; and ||||Pathology Department and paragraph sign paragraph signNephrology Department, Hôpital Tenon, APHP, Paris, France. | | Source | Clin J Am Soc Nephrol 2008 Jul 16. | | Abstract | BACKGROUND AND OBJECTIVES: Since the first description of pathology of the kidney in Waldenström disease in 1970, there have been few reports on kidney complications of IgM-secreting monoclonal proliferations. Here, we aimed to revisit the spectrum of renal lesions occurring in patients with a serum monoclonal IgM.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Fourteen patients with a circulating monoclonal IgM and a kidney disease related to B cell proliferation were identified retrospectively. Demographic, clinical, and laboratory data were assessed for each patient at the time of kidney biopsy.
RESULTS: Seven patients had a nephrotic syndrome. Patients without nephrotic syndrome all had impaired renal function. Mean serum creatinine was 238 micromol/L. For five patients, the diagnosis of monoclonal IgM preceded the kidney disease by 28.8 mo (range 12 to 60). Seven patients had Waldenström disease, two had a small B cell non-Hodgkin lymphoma, one had an IgM-excreting multiple myeloma, one had a marginal zone B cell lymphoma, and three had an IgM-related disorder. Renal lesions included (1) intracapillary monoclonal deposits disease with granular, electron-dense IgM thrombi occluding capillary lumens (5); (2) atypical membranoproliferative glomerulonephritis (3); (3) lambda light chain amyloidosis (2) associated with micro deposits in one patient; (4) acute tubular necrosis (1); and (5) CD20(+) lymphomatous infiltration (3). Remission of the nephrotic syndrome was attained in three of seven patients, and renal function improved after chemotherapy.
CONCLUSIONS: Although renal complications of IgM proliferations are rare, a wide spectrum of kidney lesions is observed, without correlation with the type of hematologic disorder. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18632851 |
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