| Title | Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit. | | Author(s) | Hollands W, Brett GM, Dainty JR, Teucher B, Kroon PA | | Institution | Institute of Food Research, Colney Lane, Norwich, UK. Fax: +44 1603 507723. | | Source | Mol Nutr Food Res 2008 Jul 21. | | Abstract | There is considerable interest in coloured fruits and berries as sources of biologically active anthocyanins. To examine the relationship between the oral dose and the amount excreted for anthocyanins from a food source across a physiological range of doses, volunteers were fed, in random order, four portions (100-400 g) of fresh strawberries as part of a standard breakfast. Urine was collected at 2 h intervals up to 8 h, and for the period 8-24 h. Fresh strawberries contained pelargonidin-3-glucoside as the major anthocyanin with smaller amounts of cyanidin-3-glucoside and pelargonidin-3-rutinoside. Anthocyanins were detected in the urine of all volunteers for all doses, predominantly as pelargonidin glucuronide and sulphate metabolites. There was a strong, linear relationship between oral dose and anthocyanin excretion (Pearson's product moment correlation coefficient = 0.692, p < 0.001, n = 40) which indicated that on an average, every additional unit of dose caused 0.0166 units of excretion. Within individuals, dose - excretion data fitted a linear regression model (median R(2) = 0.93). We conclude that strawberry anthocyanins are partially bioavailable in humans with a linear relationship between oral dose and urinary excretion for doses up to 400 g fresh fruit. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18645999 |
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