| Title | A New Indole Alkaloid and Anti-Inflammatory Constituents from Strychnos cathayensis. | | Author(s) | Chen JJ, Luo YT, Hwang TL, Sung PJ, Wang TC, Chen IS | | Institution | Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, (phone: +886-8-7624002 (ext. 332); fax: +886-8-7625308). | | Source | Chem Biodivers 2008 Jul 22; 5(7):1345-1352. | | Abstract | A new indole alkaloid, 11,12-dimethoxyhenningsamine (1), was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine (3) and aesculetin dimethyl ether (4) exhibited potent inhibition (IC(50)<5.5 mug/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18649301 |
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