Chou TH, Chen IS, Peng CF, Sung PJ, Chen JJ
A New Dihydroagarofuranoid Sesquiterpene and Antituberculosis Constituents from the Root of Microtropis japonica. [JOURNAL ARTICLE]
Chem Biodivers 2008 Jul 22; 5(7):1412-1418.
A new dihydroagarofuran-based sesquiterpene, 15-acetoxyorbiculin A (1), was isolated from the root of Microtropis japonica, together with 13 known compounds. Their structures were determined through in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, celahin C (6) and salasol A (7) exhibited potent in vitro antituberculosis activity, both with an MIC value of 15.0 mug/ml against Mycobacterium tuberculosis H(37)Rv.
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