Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial. International journal of colorectal disease [Int J Colorectal Dis] Journal article | | Title | Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial. | | Author(s) | Zingg U, Miskovic D, Pasternak I, Meyer P, Hamel CT, Metzger U | | Institution | Department of Surgery, Triemli Hospital, Birmensdorferstr. 497, 8063, Zurich, Switzerland. uzingg@uhbs.ch | | Source | Int J Colorectal Dis 2008 Dec; 23(12):1175-83. | | MeSH | Adolescent
Adult
Aged
Aged, 80 and over
Bisacodyl
Cathartics
Colon
Double-Blind Method
Female
Gastrointestinal Motility
Humans
Ileus
Male
Middle Aged
Postoperative Complications
Postoperative Period
Prospective Studies
Rectum
Surgical Procedures, Elective
| | Abstract | BACKGROUND: Postoperative ileus is a common condition after abdominal surgery. Many prokinetic drugs have been evaluated including osmotic laxatives. The data on colon-stimulating laxatives are scarce. This prospective, randomized, double-blind trial investigates the effect of the colon-stimulating laxative bisacodyl on postoperative ileus in elective colorectal resections.
MATERIALS AND METHODS: Between November 2004 and February 2007, 200 consecutive patients were randomly assigned to receive either bisacodyl or placebo. Primary endpoint was time to gastrointestinal recovery (mean time to first flatus passed, first defecation, and first solid food tolerated; GI-3). Secondary endpoints were incidence and duration of nasogastric tube reinsertion, incidence of vomiting, length of hospital stay, and visual analogue scores for pain, cramps, and nausea.
RESULTS: One hundred sixty-nine patients were analyzed, and 31 patients discontinued the study. Groups were comparable in baseline demographics. Time to GI-3 was significantly shorter in the bisacodyl group (3.0 versus 3.7 days, P = 0.007). Of the single parameters defining GI-3, there was a 1-day difference in time to defecation in favor to the bisacodyl group (3.0 versus 4.0 days, P = 0.001), whereas no significant difference in time to first flatus or tolerance of solid food was seen. No significant difference in the secondary endpoints was seen. Morbidity and mortality did not differ between groups.
CONCLUSION: Bisacodyl accelerated gastrointestinal recovery and might be considered as part of multimodal recovery programs after colorectal surgery. | | Language | eng | | Pub Type(s) | Journal Article
Randomized Controlled Trial
| | PubMed ID | 18665373 |
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