An application of UV-derivative spectrophotometry and bivariate calibration algorithm for study of photostability of levomepromazine hydrochloride. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] Journal article | | Title | An application of UV-derivative spectrophotometry and bivariate calibration algorithm for study of photostability of levomepromazine hydrochloride. | | Author(s) | Karpińska J, Sokół A, Skoczylas M | | Institution | Institute of Chemistry, University of Bialystok, ul. Hurtowa 1, 15-399 Białystok, Poland. | | Source | Spectrochim Acta A Mol Biomol Spectrosc 2008 Jun 20. | | Abstract | Derivative spectrophotometry and bivariate calibration algorithm were used for study of run of photooxidation of levomepromazine hydrochloride (LV). The actual concentrations of LV and its main degradation product levomepromazine sulphoxide (LV-SO) were calculated using data provided by applied methods. The direct reading of absorbance values at 302nm and 334nm were employed for quantification of LV and LV-SO, respectively, in the case of bivariate method. The derivative spectrophotometric method is based on transformation of zero-order spectra into first derivative. The values of first derivative at 334nm were used for quantification of LV while at 278nm for assay of LV-SO. The obtained quantitative data were applied for investigation of kinetics of photodegradation of LV. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18672397 |
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