| Title | Dantrolene: Mechanisms of Neuroprotection and Possible Clinical Applications in the Neurointensive Care Unit. | | Author(s) | Muehlschlegel S, Sims JR | | Institution | Departments of Neurology, Anesthesiology/Critical Care and Surgery, UMASS Memorial Medical Center, University Campus, University of Massachusetts Medical School, Worcester, MA, 01605, USA. | | Source | Neurocrit Care 2008 Aug 12. | | Abstract | Calcium plays a central role in neuronal function and injury. Dantrolene, an inhibitor of the ryanodine receptor, inhibits intracellular calcium release from the sarco-endoplasmic reticulum. We review the available data of dantrolene as a potential neuroprotective agent and briefly summarize its other pharmacologic effects that may have potential applications for patients in the neurointensive care unit (NICU). Areas with the need for continued research are identified. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18696266 |
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