| Title | Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B. | | Author(s) | Lv YY, Shi BY, Guo H | | Institution | Department of Endocrinology, First Affiliated Hospital, Medical School of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi Province, China. shibingy@126.com. | | Source | World J Gastroenterol 2008 Aug 7; 14(29):4713-5. | | Abstract | We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-alpha) 2b. The patient presented with polydipsia, polyuria, hyperglycemia, diabetic ketoacidosis, combined with C-peptide secretion deficiency and positive islet cell autoantibody (ICAb). IFN-alpha 2b treatment was terminated and instead insulin treatment was initiated. Five months after cessation of the recombinant human IFN-alpha 2b therapy, the patient remained insulin-dependent. Her serum HBV DNA became negative and serum transaminase returned to the normal level after a 10-mo period of IFN therapy. Type 1 DM induced by IFN-alpha is relatively rare in patients with chronic hepatitis B. We should pay more attention to patients on IFN-alpha therapy to avoid destruction of pancreatic beta cells. This is the first case report from China. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18698691 |
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