| Title | Significance of the injection timing of ephedrine to reduce the onset time of rocuronium. | | Author(s) | Han DW, Chun DH, Kweon TD, Shin YS | | Institution | Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. | | Source | Anaesthesia 2008 Aug; 63(8):856-60. | | MeSH | Adult
Androstanols
Anesthesia, General
Blood Pressure
Drug Administration Schedule
Drug Synergism
Ephedrine
Heart Rate
Humans
Injections, Intravenous
Intubation, Intratracheal
Male
Middle Aged
Neuromuscular Nondepolarizing Agents
Preanesthetic Medication
Vasoconstrictor Agents
| | Abstract | We postulated that the onset time of rocuronium can be accelerated effectively if it is administered at the time when the effect of ephedrine on cardiac output has reached its maximum. Seventy-five male, anaesthetised, patients were randomly allocated to three groups. Ephedrine 70 microg.kg(-1) was administered at 4 min (Early) or 30 s (Late) before administering rocuronium. The control group received saline at 4 min and at 30 s before rocuronium. The onset time of rocuronium in the Early group was significantly shorter than in the Control group, but there was no difference in the onset time between the Late and Control groups. There were no significant differences in the intubating conditions of the three groups. Ephedrine 70 microg.kg(-1) can reduce the onset time of rocuronium effectively if rocuronium is administered at 4 min following the ephedrine injection, when the effect of ephedrine on cardiac output is expected to reach its maximum. | | Language | eng | | Pub Type(s) | Journal Article
Randomized Controlled Trial
| | PubMed ID | 18699898 |
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