| Title | [A case of advanced gastric cancer successfully treated with s-1 and Paclitaxel followed by curative resection.] | | Author(s) | Fukuda N, Sugiyama Y, Wada J, Niki M, Nomoto T | | Institution | Dept. of Surgery, Mizonokuchi Hospital, Teikyo University School of Medicine. | | Source | Gan To Kagaku Ryoho 2008 Aug; 35(8):1379-82. | | Abstract | A 59-year-old man diagnosed with Stage IV advanced gastric cancer due to pancreatic invasion(T4)and splenic hilum lymph node metastasis(N3)was initially treated with neoadjuvant chemotherapy using S-1 and CDDP. However, it was discontinued because the tumor marker increased after 1 course. Instead of S-1 and CDDP, S-1 and paclitaxel were then administered. After 4 courses, CT scan revealed reduced tumor size and the disappearance of splenic hilum lymph node swelling that indicated PR of the chemotherapy. Moreover, serum CEA was remarkably decreased to 77 ng/mL from 1,092 ng/mL. He could undergo subtotal gastrectomy(Billroth II)with lymph node dissection(D2)and cholecystectomy. Histopathological examination revealed Stage II(pT2(SS), pN1, CY0, ly1, v2)advanced gastric cancer that showed good effect of S-1 and paclitaxel. At this writing(October 2007), the patient has remained free of disease for more than 1 year and 6 months with good nutrition. Neoadjuvant chemotherapy using S-1 and paclitaxel for advanced gastric cancer seems to have been effective. | | Language | jpn | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 18701853 |
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