[Three cases of stomatitis caused by chemotherapy for gastrointestinal cancer that responded well to lafutidine.] Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] Journal article

We described 3 cases of stomatitis caused by chemotherapy with the fluoropyrimidine preparation S-1, alone or combined with other anticancer drugs. The stomatitis did not respond to conventional oral mucosal treatment such as triamcinolone acetonide(Kenalog)or allopurinol, but improved after treatment with the histamine H2-receptor antagonist lafutidine. The concurrent use of lafutidine allowed these 3 patients to continue chemotherapy with no recurrence of stomatitis. We concluded that lafutidine may be a viable treatment option for chemotherapy-induced stomatitis, allowing treatment to be continued.

Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho]