Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice. Diabetes research and clinical practice [Diabetes Res Clin Pract] Journal article | | Title | Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice. | | Author(s) | Kang YJ, Jung UJ, Lee MK, Kim HJ, Jeon SM, Park YB, Chung HG, Baek NI, Lee KT, Jeong TS, Choi MS | | Institution | Department of Food Science and Nutrition, Kyungpook National University, Daegu 702-701, South Korea. | | Source | Diabetes Res Clin Pract 2008 Oct; 82(1):25-32. | | MeSH | Animals
Artemisia
Blood Glucose
Body Weight
Diabetes Mellitus, Type 2
Eating
Flavonoids
Glucose
Glucose Tolerance Test
Glucose-6-Phosphatase
Hemoglobin A, Glycosylated
Insulin
Insulin-Secreting Cells
Liver
Liver Glycogen
Male
Mice
Mice, Inbred C57BL
Pancrelipase
Phosphoenolpyruvate Carboxykinase (GTP)
| | Abstract | Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) was isolated from Artemisia princeps to investigate the dose-response effects on blood glucose regulation and pancreatic beta-cell function in type 2 diabetic mice. Db/db mice were divided into control (eupatilin-free, AIN-76 standard diet), low-Eupa (0.005g/100g diet) and high-Eupa (0.02g/100g diet) groups. The supplementation of eupatilin for 6 weeks significantly lowered fasting blood glucose concentration while it increased hepatic glycogen content. In particular, high-Eupa reduced hemoglobin A(1c) and plasma glucagon levels along with a simultaneous increase in plasma insulin and adiponectin levels. The supplementation of eupatilin significantly lowered hepatic glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities, while it increased glucokinase activity in the liver. The pancreatic insulin concentration was higher in the eupatilin-supplemented groups. Also the pancreatic insulin concentration of eupatilin groups was higher than the control group. These results suggest that eupatilin played the role of an antidiabetic functional component in A. princeps by enhancing hepatic and plasma glucose metabolism as well as by increasing insulin secretion in type 2 diabetic mice. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18703253 |
|
|
| |
Advertise on this site.
| | |
|
