| Title | Mechanism of in vitro percutaneous absorption enhancement of carvedilol by penetration enhancers. | | Author(s) | Amin S, Kohli K, Khar RK, Mir SR, Pillai KK | | Institution | Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India. daneshyarsaima@yahoo.com | | Source | Pharm Dev Technol 2008; 13(6):533-9. | | MeSH | 2-Propanol
Adjuvants, Pharmaceutic
Animals
Calorimetry, Differential Scanning
Carbazoles
Clove Oil
Epidermis
Eucalyptus
Female
Nigella sativa
Oleic Acid
Plant Oils
Polysorbates
Propanolamines
Rats
Rats, Wistar
Skin
Skin Absorption
Spectroscopy, Fourier Transform Infrared
Transition Temperature
Vasodilator Agents
| | Abstract | The effect of penetration enhancers like tulsi (basil) oil, eucalyptus oil, clove oil, black cumin oil, oleic acid and Tween 80 on the percutaneous absorption of model lipophilic drug-carvedilol was investigated using excised rat abdominal skin. Transdermal flux, permeability coefficient and enhancement factor were calculated for each penetration enhancer. Black cumin oil (5% v/v) was selected on the basis of its highest enhancement in permeation and was evaluated further for its mode of action using DSC, FTIR and histological studies. The results indicated that the oil shows its action by extraction of lipids from stratum corneum as well as by loosening the hydrogen bonds between ceramides subsequently leading to fluidization of the lipid bilayer. | | Language | eng | | Pub Type(s) | In Vitro
Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18720242 |
|
