| Title | [Influence of Zea mays L. saponin (ZMLS) on ultrastructure of kidney and pancreas in diabetes rats induced by streptozocin] | | Author(s) | Miao MS, Zhang GL, Miao YY, Shi JJ, Liu HL | | Institution | Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China. miaomingsan@163.com | | Source | Zhongguo Zhong Yao Za Zhi 2008 May; 33(10):1179-83. | | Abstract | OBJECTIVE: To discuss the effect of Zea mays L. saponin (ZMLS) on ultrastructure of kidney and pancreas in the diabetes rats induced by streptozocin.
METHOD: The diabetic rat model was established by injections of STZ, blood glucose, the ultrastructure of the kidney and pancreas were observed. Result: Compared with the model group, the large, middle-dose ZMLS groups and melbinum group could remarkably decrease the blood glucose (P < 0.01), the large, middle, small-dose ZMLS groups could remarkably prevent the pancreatic islet beta-cell from the injury induced by Streptozotocin. Melbinum and the large, middle-dose ZMLS groups could remarkably increase mitochondrial Vv, deltam and euchromatin Vv (P < 0.01), and significantly decrease the delta, Nucleus delta and heterochromatin Vv (P < 0.01). The small dose of ZMLS obviously increases mitochondrial Vv (P < 0.05).
CONCLUSION: ZMLS showed good effect on decreasing blood glucose and protection action on the kidney and pancreas injury of induced by STZ. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 18720872 |
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