Muramatsu T, Nakamura Y, Shibuya A, Suzuki H, Ando M
[Recurrence of severe hypophosphatemia associated with tumor neogenesis in a patient with acute lymphocytic leukemia who experienced acute renal failure due to tumor lysis syndrome] [English Abstract, Journal Article]
Nippon Jinzo Gakkai Shi 2008; 50(5):602-5.
We report a 47-year-old male patient with acute lymphocytic leukemia (ALL) who showed recurrent severe hypophosphatemia. Chemotherapy for ALL induced tumor lysis syndrome requiring hemodialysis therapy. Thereafter, severe hypophosphatemia (serum phosphorus concentration less than 0.7 mg/dL) was observed several days before an acute rise in peripheral lymphoblast cell counts due to recurrence of ALL. This hypophosphatemia soon returned to a higher than normal level by treating leukemic cells with anti-cancer agents. This event occurred twice in his clinical course. The laboratory tests strongly suggested that this hypophosphatemia was induced by a shift of phosphorus into leukemic cells that rapidly replicated in the tissues.
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